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Learn about the Risks Associated with Prempro

Learn about the Risks Associated with Prempro

Hormone replacement therapy, or HRT, is one choice for women that are experiencing the persistent and painful maladies associated with low estrogen levels. In order to address the imbalance, HRT medications such as Prempro, Premarin, and Estrace seek to mimic natural chemicals found throughout the body, boosting hormone levels with pills, estrogen cream, and other methods. Hysterectomies, ovarian cancer and other complications of the ovaries, and menopause can call cause this drastic change to occur. Symptoms of this common chemical imbalance include, but are not limited to the following:

  • Hot flashes

  • Vaginal dryness

  • Vaginal burning

  • Vaginal irritation

The popular drug Prempro was designed by Wyeth Pharmaceuticals to address these problems. By collecting estrogen from various places in nature, they created a pill that mimics those that naturally occur within the normal human female. Interestingly, most of the natural estrogen originally came from pregnant horses. However, as the medication became more popular and was prescribed by more doctors, many patients began reporting painful, sometimes deadly, side effects.

The range of issues and complications arising from regular Prempro use is quite wide. Some are merely annoying, while others can plague women with pain for years. Commonly reported non-lethal problems include, but are not limited to:

  • Breast pain and unusual swelling

  • Abdominal pain from “bloating” or atypical fluid retention

  • Mild headaches and dizziness

  • Decreased sex drive

  • Increased amounts of acne and hair growth 

However, the fact that the situations listed above are non-lethal does not mean that they are not indicators of larger, more deadly problems lurking beneath or in the future with respect to Prempro. While many women will not experience them, but a serious concern for women who take Prempro is that they could be at an increased risk for the following:

  • Breast cancer (usually after 4 or more years on therapy)

  • Ovarian cancer

  • Blood clots that can lead to stroke

  • Heart attack

  • Gall bladder disease


Note that the risk of cancer is generally, though not always, associated with oral estrogens such as Prempro, rather than vaginal creams. Typically, the increased risk does not occur until after 4 or more years of constant HRT therapy. Of course, this is not always true, and some women may develop problems sooner. Some patients may experience no adverse effects at all. Also note that the ailments listed above can plague women for as long as they continue to take the medication.

If you or anyone you know has ever taken Prempro or any of the other drugs listed above, and are feeling unwell, be sure to contact a doctor right away. Once you obtain verified documentation of your pain and suffering, team with a qualified injury attorney with experience in drug injuries. Don't wait. Failure to discover and secure your legal rights as soon as possible could result in missing out on monetary, or other forms of compensation to which you have a legal right.

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